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From Buffalo Airport:
Follow signs from the airport to 33 West. Take the exit to I-90W towards Erie. From the I-90 in Buffalo take exit 53 to the 190 north. Take exit 9 off of the 190 which leads to the Peace Bridge to Canada. After clearing customs, you will be on the Queen Elizabeth Highway (QEW). Follow the QEW north into Niagara Falls.
From Toronto/Pearson International Airport:
When exiting the airport, follow signs to the 401 west. Follow the 401 to the 427 South. Follow the QEW into Niagara Falls and exit at the Niagara Veterans Memorial Highway (formerly HWY 420) Bridge to USA.